Miss Morissa is a dramatic, moving novel of a young pioneering woman doctor on the brawling Nebraska frontier of the 1870s.

Fleeing the East and a heartbreaking past, Morissa Kirk finds the North Platte River Valley rife with rumors of gold strikes. Fortune hunters, desperadoes, horse thieves, murderers make up the frontier society, while Indians roam the plains refusing to surrender their land to the gold-hungry white men. Near lawless Clarke Bridge she sets up her practice, treating white and Indian alike, receiving horses (if anything) in return for her services. Then, even as fame spreads of her skill, and acceptance slowly grows, Morissa becomes embroiled in the life-and-death struggle between the cattlemen and the homesteaders, a struggle as destructive as it was inevitable. In the telling of Morissa's story, Mari Sandoz has caught the whole turmoil of the changing frontier in the days of Custer, Calamity Jane, and Buffalo Bill Cody.