When ace high school detective Jimmy Kudo is fed a mysterious substance by a pair of evil men in black he is physically transformed into a first grader. Until Jimmy can find a cure for his miniature malady, he takes on the pseudonym Conan Edogawa and continues to solve all the cases that come his way. Conan isn't sure whether to trust Jodie Saintemillion, the American high school teacher whose ditzy blonde exterior conceals a calculating mind. When a bus is hijacked by desperate criminals, Ms. Saintemillion turns out to be cannier than Conan ever imagined, revealing a head for crime solving and a body for kicking butt. But Anita can't help noticing that wherever Conan's beautiful, mysterious new ally goes, the Syndicate never seems to be far behind.