This book constitutes the proceedings of the 19th International Conference on Service-Oriented Computing, ICSOC 2020, which is held virtually in November 2021.The 29 full, 28 short, and 3 vision papers included in this volume were carefully reviewed and selected from 189 submissions. They were organized in topical sections named: Blockchains and smart contracts, Architectures, microservices and APIs, Applications, Internet-of-Things, crowdsourced, social, and conversational services, Service composition and recommendation, Cloud computing, and Edge computing.