This book constitutes the Third Diabetic Foot Ulcers Grand Challenge, DFUC 2022, which was held on September 2022, in conjunction with the 25th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2022 in Singapore. The 8 full papers presented together with 5 challenge papers and 3 post-challenge papers included in this book were carefully reviewed and selected from 19 submissions.The DFU challenges aim to motivate the health care domain to share datasets, participate in ground truth annotation, and enable data-innovation in computer algorithm development. In the longer term, it will lead to improved patient care.