The book is a collection of best selected research papers presented at 2nd International Conference on Advances in Computational Intelligence and Informatics (ICACII 2023) organized by Anurag University, Hyderabad, India, during 22–23 December 2023. It includes innovative ideas and new research findings in the field of Computational Intelligence and Informatics which is useful for researchers, scientists, technocrats, academicians, and engineers. The areas included are high performance system, data science and analytics, computational intelligence and expert systems, cloud computing, computer network, and emerging technologies.