This book gathers original papers reporting on innovative methods and tools in design, modelling, simulation and optimization, and their applications in engineering design, manufacturing and other relevant industrial sectors. Topics span from advances in geometric modelling, applications of virtual reality, innovative strategies for product development and additive manufacturing, human factors and user-centered design, engineering design education and applications of engineering design methods in medical rehabilitation and cultural heritage. Chapters are based on contributions to the Second International Conference on Design Tools and Methods in Industrial Engineering, ADM 2021, held on September 9–10, 2021, in Rome, Italy, and organized by the Italian Association of Design Methods and Tools for Industrial Engineering, and Dipartimento di Ingegneria Meccanica e Aerospaziale of Sapienza Università di Roma, Italy. All in all, this book provides academics and professionals with a timely overview and extensive information on trends and technologies in industrial design and manufacturing.