This book constitutes the revised selected papers of the 25th International Conference on Mathematical Modeling and Supercomputer Technologies, MMST 2025, held in Nizhny Novgorod, Russia, during November 17–19, 2025.

The 21 full papers and 3 short papers included in this book were carefully reviewed and selected from 41 submissions. They are organized in topical sections as follows: Artificial intelligence and Supercomputer Simulation; Computing in Optimization and Optimal Control; and Computational Methods for Mathematical Models Analysis.