State-of-the-art and novel methodologies and technologies allow researchers, designers, and domain experts to pursue technology-enhanced learning (TEL) solutions targeting not only cognitive processes but also motivational, personality, or emotional factors. The International Conference in Methodologies and Intelligent Systems for Technology-Enhanced Learning (MIS4TEL'21) is hosted by the University of Salamanca and was held in Salamanca (Spain) from October 6–8, 2021. The annual appointment of MIS4TEL established itself as a consolidated fertile forum where scholars and professionals from the international community, with a broad range of expertise in the TEL field, share results and compare experiences. The calls for papers of the 11th edition of the conference welcomed novel research in TEL and expands on the topics of the previous editions: It solicited work from new research fields (ranging from artificial intelligence and agent-based systems to robotics, virtual reality, Internet of things and wearable solutions, among others) concerning methods and technological opportunities, and how they serve to create novel approaches to TEL, innovative TEL solutions, and valuable TEL experiences.