This book constitutes refereed proceedings of the 2nd International Semantic Intelligence Conference (ISIC 2022). This book covers a wide range of topics, including semantic web engineering, ontology-based data access, multimodal and multilingual access, machine-to-machine communications and interoperability, knowledge extraction and ontology learning from the web, computational paradigms and computational intelligence, distributed and mobile systems, and many others. This book includes novel contributions and the latest developments from researchers across industry and academia. This book serves as a valuable reference resource for academics and researchers across the globe.