This volume contains the papers presented at INDIA-2012: International conference on  Information system Design and Intelligent Applications held on January 5-7, 2012 in Vishakhapatnam, India. This conference was organized by Computer Society of India (CSI), Vishakhapatnam chapter well supported by Vishakhapatnam Steel, RINL, Govt of India. It contains 108 papers contributed by authors from six different countries across four continents. These research papers mainly focused on intelligent applications and various system design issues. The papers cover a wide range of topics of computer science and information technology discipline ranging from image processing, data base application, data mining, grid and cloud computing, bioinformatics among many others. The various intelligent tools like swarm intelligence, artificial intelligence, evolutionary algorithms, bio-inspired algorithms have been applied in different papers for solving various challenging IT related problems.