In this issue of Orthopedic Clinics, guest editors from the esteemed Campbell Clinic bring their considerable expertise to the topic of Unique or Select Procedures. Unique or select procedures encompass specialized techniques and advanced interventions designed to address complex or atypical musculoskeletal conditions that standard approaches may not adequately resolve. This issue reflects a broader trend toward precision medicine in orthopedics-aiming to deliver highly individualized, effective, and innovative treatments that push the boundaries of traditional surgical care.