The present work is aimed at developing the modified modern electroanalytical methods for the determination of the selected model drugs in dosage forms including phytochemicals and pharmaceutical formulation. Different types of nanomaterias and surfactants have been used to fabricate electrochemical sensors. Procedures have been standardized for the qualitative and quantitative analysis of some pharmaceuticals in solubilized systems. The developed methods are advantageous over other sophisticated and time consuming techniques in being low cost, rapid, ease in sample handling, and above all, extremely high sensitivity and are thus the methods of choice for the detection and trace-level determination of molecules of interest.