This book presents the key problems in morphogenesis from a cell biological perspective. Each key problem is addressed in multiple chapters with each chapter providing a balanced, interdisciplinary perspective. Topics covered include the interplay between genetics, microenvironment and physical forces in morphogenesis, mechanotransduction and feedback regulatory systems, tissue-wide systems coordinating cellular responses and molecular mechanisms modifying tissue specific morphogenesis. The book employs emerging techniques and experimental paradigms in morphogenesis and illustrates how evolution modifies or generates new morphogenetic modules.