This work contains fully refereed papers from the 15th Annual Symposium on High Performance Computing. These papers cover both fundamental and applied topics in HPC: parallel algorithms, distributed systems and architectures, distributed memory and performance, high level applications, tools and solvers, numerical methods and simulation, advanced computing systems, and the emerging area of computational grids. The book should be suitable as a secondary text for graduate level courses, and as a reference for researchers and practitioners in industry.