The study was conducted to develop Lactoferrin and TonB dependent receptor database, prediction of lactoferrin like proteins in plant and other resources, feasible prediction of Lactoferrin like sequences including domain and motif of theses sequences and ancestral relationship of these proteins with lactoferrin using phylogenetic analysis. Database was developed after retrieving data from different servers by using similarity search by blastp. The MSAccess was used to developed backhand whereas front hand created by JSP, JAVA, HTML and CSS. Tomcat Server v5.0 used for connection between front-hand with back hand. Feasible structures was found by using blastp against protein databank as the lactoferrin like protein seq from Ricinus communis, found homology with 1N76 based on e-value and bit score with percent identities. This structure was shared common domains with regular expression of Homo sapiens lactoferrin.