This handbook is a clinically-focused guide on the diagnosis and evidence-based treatment of migraine, the third most common medical condition on the planet. It is a concise yet thorough guide for management of migraine in clinical practice settings as informed by current scientific literature and clinical guidelines. This handbook incorporates diagnostic criteria from the most recent edition of the International Classification of Headache Disorders (ICHD-3). The first half of the handbook provides information on assessment of migraine (including headache red flags and indications for neuroimaging), screening for common comorbid conditions, and essential lifestyle recommendations for all migraine patients. The second half covers both acute and preventive headache medications and relevant treatment algorithms and indications, as well as other medical therapies and behavioral interventions for migraine. This clinician’s manual is easy to read and includes numerous tables and other content valuable to all providers wanting a go-to resource on clinical management of migraine. It is an ideal companion for busy general practitioners and neurologists, nurses and mid-level providers, neurology trainees and residents, as well as patients wishing to gain a better understanding of their condition.