This book constitutes the thoroughly refereed post-workshop proceedings of the First WICI International Workshop on Web Intelligence meets Brain Informatics, WImBI 2006, which was held in Beijing, China, in December 2006. The workshop explores a new perspective of Web Intelligence (WI) research from the viewpoint of Brain Informatics (BI). The 26 revised full-length papers presented together with three introductory lectures have been carefully reviewed and selected.