Demonstrating how biostatistics helps manage medical uncertainties, this comprehensive edition covers numerous biostatistical methods used in evidence-based patient management, medical research, and health administration. New chapters describe clinical trials, observational studies, laboratory experiments, survival analysis, logistic regression, and clinimetrics. With more real-world examples, this edition also expands discussions on epistemic uncertainties, crossover designs, and equivalence trials. In addition to conventional statistical procedures, it discusses reliability and validity evaluations, quality control methods, and the robustness of results.