This book explores the domain of signal processing using Python, with the help of working examples and accompanying code. The book introduces the concepts of Python programming via signal processing with numerous hands-on examples and code snippets. The book will enable readers to appreciate the power of Python in this field and write their code to implement complex signal processing algorithms such as signal compression, cleaning, segmentation, decomposition, and feature extraction and be able to incorporate machine learning models using relevant Python libraries. This book aims to bring together professionals from academia and industry to ignite new developments and techniques in the domain of signal processing with Python.