Completely revised and updated, the second edition of this classic text retains its predecessor's careful balance of theory and practice while incorporating new approaches, more data sets, and a broader scope. Enhancements in this edition include a new chapter on bioequivalence, methods for analyzing longitudinal continuous and categorical data, extensive real-life examples, and SAS code that allows readers to implement the analyses described. With downloadable SAS programs, thorough treatment of design issues, and a comprehensive catalog of designs, this edition sets a new standard for texts in this area and will undoubtedly be of direct practical value for years to come.