The two-volume set LNCS 10587 + 10588 constitutes the refereed proceedings of the 16th International Semantic Web Conference, ISWC 2017, held in Vienna, Austria, in October 2017. ISWC 2017 is the premier international forum, for the Semantic Web / Linked Data Community. The total of 55 full and 21 short papers presented in this volume were carefully reviewed and selected from 300 submissions. They are organized according to the tracks that were held: Research Track; Resource Track; and In-Use Track.