This open access book explores how innovative urban governance and digital technologies can be strategically managed to enhance citizens’ quality of life. It examines the integration of smart infrastructures, data-driven decision-making, and participatory policies to promote social, environmental, and economic wellbeing. Through interdisciplinary perspectives and real-world case studies, it highlights how city managers can balance efficiency, sustainability, and inclusiveness. Emphasis is placed on human-centered approaches, ethical use of technology, and collaborative ecosystems involving public institutions, private actors, and communities. The book provides practical insights for policymakers, urban planners, and researchers seeking to build smarter and healthier cities.