This book constitutes the proceedings of the 10th International Conference on Future Data and Security Engineering. Big Data, Security and Privacy, Smart City and Industry 4.0 Applications, FDSE 2023, held in Da Nang, Vietnam, during November 22–24, 2023.The 38 full papers and 8 short papers were carefully reviewed and selected from 135 submissions. They were organized in topical sections as follows: big data analytics and distributed systems; security and privacy engineering; machine learning and artificial intelligence for security and privacy; smart city and industry 4.0 applications; data analytics and healthcare systems; and short papers: security and data engineering.