The current treatment modalities of periodontal diseases is non-specific and centered to mechanical debridement (surgical or non surgical) along with antibiotics. Therapy is costly and painful and has in a variable prognosis due in part to poor patients compliance. Vaccination may be important adjunctive therapy to mechanical debridement in near future.Understanding the nature of periodontopatic bacterias and their critical antigens will provide us better opportunity to develop a safe and effective immunization against periodontal disease. The paradigm shift of periodontal vaccine from myth to reality will surely occur in near future with proper research and clinical implication.