This book gathers high-quality research papers presented at the 5th International Conference on Frontiers in Computing and Systems (COMSYS 2024) held at BITS Pilani K K Birla Goa Campus, Goa, India, during December 13 – 15, 2024. The book covers research in AI, machine learning, and data science; devices, circuits, and systems; computational biology, biomedical informatics, and network medicine; communication networks, cloud computing and IoT; image, video and signal processing; and security and privacy.