This book contains the proceedings of the Fourth Meeting on CPT and Lorentz Symmetry, held at Indiana University in Bloomington on August 8-11, 2007. The Meeting focused on experimental tests of these fundamental symmetries and on important theoretical issues, including scenarios for possible relativity violations.Experimental subjects covered include: astrophysical observations, clock-comparison measurements, cosmological birefringence, electromagnetic resonant cavities, gravitational tests, matter interferometry, muon behavior, neutrino oscillations, oscillations and decays of neutral mesons, particle-antiparticle comparisons, post-Newtonian gravity, space-based missions, spectroscopy of hydrogen and antihydrogen, and spin-polarized matter. Theoretical topics covered include: physical effects at the level of the Standard Model, General Relativity, and beyond; the possible origins and mechanisms for Lorentz and CPT violations; and associated issues in field theory, particle physics, gravity, and string theory. Contributors consist of the leading experts in this very active research field.