In the quest to understand and model healthy or sick human body functions, researchers and medical doctors are utilizing more and more quantitative tools and techniques. This trend is advancing the development of the new field of biomedical computing, which is an interface between signal processing, pattern recognition, optimization, nonlinear dynamics, computer science and biology, chemistry and medicine. This volume contains a collection of refereed papers. Included are contributions in genomics, global optimization in biomedicine, computational neuroscience, FMRI, brain dynamics, epileptic seizure prediction and cancer diagnostics.