This book is a collection of best selected research papers presented at Second International Conference on Intelligent Systems and Sustainable Computing (ICISSC 2022), held in School of Engineering, Malla Reddy University, Hyderabad, India, during December 16–17, 2022. The book covers recent research in intelligent systems, intelligent business systems, soft computing, swarm intelligence, artificial intelligence and neural networks, data mining and data warehousing, cloud computing, distributed computing, big data analytics, Internet of things (IoT), machine learning, speech processing, sustainable high-performance systems, VLSI and embedded systems, image and video processing and signal processing and communication.