This book is a valuable source for graduate students and researchers and provides a comprehensive introduction to recent theories and applications of mathematical modeling and numerical simulation. It includes selected peer-reviewed papers presented at the 4th International Conference on Mathematical Modelling, Applied Analysis and Computation (ICMMAAC 2021), held at JECRC University, Jaipur, India, during August 5–7, 2021. The book is focused on mathematical modeling of various problems arising in science and engineering and new efficient numerical approaches for solving linear nonlinear problems and rigorous mathematical theories, which can be used to analyze different kinds of mathematical models. Applications of mathematical methods in physics, chemistry, biology, mechanical engineering, civil engineering, computer science, social science, and finance are presented.