This book discusses the potential application of self-nanoemulsifying drug delivery systems (SNEDDS) in different inflammatory diseases. It introduces the fundamental principles of SNEDDS, their formulation components, and characterization techniques, providing insights into their mechanisms of drug delivery and formulation optimization. The book also explores the potential of various combination therapies with SNEDDS, highlighting strategies, synergistic effects, and challenges. Furthermore, the chapters in the book highlight the applications of SNEDDS in specific inflammatory diseases, including diabetes, brain diseases, colorectal diseases, cardiovascular diseases, lung diseases, and cancer. Towards the end, the book evaluates the potential toxic effects of SNEDDS components and addresses safety considerations, regulatory aspects, patents, and clinical trials pertaining to SNEDDS. This book is intended for researchers, pharmacologists, pharmaceutical scientists, and clinicians involved in drug delivery and nanomedicine.