The four-volume set LNCS 6765-6768 constitutes the refereed proceedings of the 6th International Conference on Universal Access in Human-Computer Interaction, UAHCI 2011, held as Part of HCI International 2011, in Orlando, FL, USA, in July 2011, jointly with 10 other conferences addressing the latest research and development efforts and highlighting the human aspects of design and use of computing systems. The 70 revised papers included in the second volume were carefully reviewed and selected from numerous submissions. The papers are organized in the following topical sections: user models, personas and virtual humans; older people in the information society; designing for users diversity; cultural and emotional aspects; and eye tracking, gestures and brain interfaces.