This book constitutes thoroughly reviewed, revised and selected papers from the 4th International Conference on Human Centered Computing, HCC 2018, held in Merida, Mexico, in December 2018. The 50 full and 18 short papers presented in this volume were carefully reviewed and selected from a total of 146 submissions. They focus on a "hyper-connected world", dealing with new developments in artificial intelligence, deep learning, brain-computing, etc.