This book constitutes the refereed proceedings of the 6th International Symposium on Integrated Uncertainty in Knowledge Modelling and Decision Making, IUKM 2018, held in Hanoi, Vietnam, in March 2018.The 39 revised full papers presented in this book were carefully reviewed and selected from 76 initial submissions. The papers are organized in topical sections on uncertainty management and decision support; clustering and classification; machine learning applications; statistical methods; and econometric applications.