This book provides a comprehensive exploration of AI-driven approaches to strengthening CPS security. Cyber-physical systems (CPSs) form the foundation of modern infrastructure, connecting physical processes with digital intelligence across domains such as health care, manufacturing, energy, and transportation. While CPS enables efficiency and innovation, their growing complexity also exposes them to significant cybersecurity risks. Artificial intelligence offers powerful solutions to these challenges, enabling intelligent monitoring, anomaly detection, intrusion prevention, and secure communication.