The third edition of the Handbook of Technological Pedagogical Content Knowledge (TPACK) for Educators addresses the concept and implementation of technological pedagogical content knowledge. One of the most highly cited and widely recognized frameworks in educational technology, the TPACK construct provides teachers with the knowledge and skills they need to meaningfully integrate technology into teaching in specific content areas. This thorough, substantive revision explores the emerging theoretical developments, empirical efforts, digital technologies, and diverse contextual factors that impact TPACK’s evolution and enactment around the world. Critical perspectives on TPACK, research on its deployment across specific content areas, and integration into teacher education and professional development frame a variety of new and updated chapters covering research methods, contextual knowledge, artificial intelligence, and more. The Handbook of Technological Pedagogical Content Knowledge (TPACK) for Educators is simultaneously a mandate and a manifesto on engagement with technology in today’s classrooms.