Using large amounts of chemical fertilizers to maximize crop yields lead to increased nitrate leaching into groundwater, deteriorating effects on the soil to see. As a general rule, feed the soil, not the plant, but the extra feed does not make extra strong plants, while the additional N supply can result in masses of foliage at the expense of fruit production and inviting insect pest and lodging of crop. So there must be a balanced use of fertilizers with organic amendments for sustainable farming, soil life and human life indirectly. These lines indicate the great importance of organic agriculture. Infect organic agriculture is the form of agriculture that is based on techniques such as crop rotation, green manures, compost and bio-sludge application on soil and biological pest control to maintain soil productivity. Application of bio-slurry and compost and their effect on crop growth, yield, NPK use efficiency and soil residual effect described in this manuscript. multi-dimensional benefits of bio-slurry and compost application in soil for sustainable agriculture, environment and quality of life are suggested here, resulted in a tendency for organic agriculture.